Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2.
Identifieur interne : 000471 ( an2020/Analysis ); précédent : 000470; suivant : 000472Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2.
Auteurs : Zhixin Liu [République populaire de Chine] ; Xiao Xiao [République populaire de Chine] ; Xiuli Wei [République populaire de Chine] ; Jian Li [République populaire de Chine] ; Jing Yang [République populaire de Chine] ; Huabing Tan [République populaire de Chine] ; Jianyong Zhu [République populaire de Chine] ; Qiwei Zhang [République populaire de Chine] ; Jianguo Wu [République populaire de Chine] ; Long Liu [République populaire de Chine]Source :
- Journal of medical virology [ 1096-9071 ] ; 2020.
Abstract
From the beginning of 2002 and 2012, severe respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) crossed the species barriers to infect humans, causing thousands of infections and hundreds of deaths, respectively. Currently, a novel coronavirus (SARS-CoV-2), which has become the cause of the outbreak of Coronavirus Disease 2019 (COVID-19), was discovered. Until 18 February 2020, there were 72 533 confirmed COVID-19 cases (including 10 644 severe cases) and 1872 deaths in China. SARS-CoV-2 is spreading among the public and causing substantial burden due to its human-to-human transmission. However, the intermediate host of SARS-CoV-2 is still unclear. Finding the possible intermediate host of SARS-CoV-2 is imperative to prevent further spread of the epidemic. In this study, we used systematic comparison and analysis to predict the interaction between the receptor-binding domain (RBD) of coronavirus spike protein and the host receptor, angiotensin-converting enzyme 2 (ACE2). The interaction between the key amino acids of S protein RBD and ACE2 indicated that, other than pangolins and snakes, as previously suggested, turtles (Chrysemys picta bellii, Chelonia mydas, and Pelodiscus sinensis) may act as the potential intermediate hosts transmitting SARS-CoV-2 to humans.
DOI: 10.1002/jmv.25726
PubMed: 32100877
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000460
- to stream PubMed, to step Curation: 000460
- to stream PubMed, to step Checkpoint: 000440
- to stream Ncbi, to step Merge: 000949
- to stream Ncbi, to step Curation: 000949
- to stream Ncbi, to step Checkpoint: 000949
- to stream Main, to step Merge: 000473
- to stream Main, to step Curation: 000471
- to stream Main, to step Exploration: 000471
- to stream an2020, to step Extraction: 000471
Links to Exploration step
pubmed:32100877Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2.</title><author><name sortKey="Liu, Zhixin" sort="Liu, Zhixin" uniqKey="Liu Z" first="Zhixin" last="Liu">Zhixin Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan</wicri:regionArea><wicri:noRegion>Shiyan</wicri:noRegion></affiliation></author><author><name sortKey="Xiao, Xiao" sort="Xiao, Xiao" uniqKey="Xiao X" first="Xiao" last="Xiao">Xiao Xiao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan</wicri:regionArea><wicri:noRegion>Shiyan</wicri:noRegion></affiliation></author><author><name sortKey="Wei, Xiuli" sort="Wei, Xiuli" uniqKey="Wei X" first="Xiuli" last="Wei">Xiuli Wei</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan</wicri:regionArea><wicri:noRegion>Shiyan</wicri:noRegion></affiliation></author><author><name sortKey="Li, Jian" sort="Li, Jian" uniqKey="Li J" first="Jian" last="Li">Jian Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan</wicri:regionArea><wicri:noRegion>Shiyan</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Jing" sort="Yang, Jing" uniqKey="Yang J" first="Jing" last="Yang">Jing Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan</wicri:regionArea><wicri:noRegion>Shiyan</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Huabing" sort="Tan, Huabing" uniqKey="Tan H" first="Huabing" last="Tan">Huabing Tan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan</wicri:regionArea><wicri:noRegion>Shiyan</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Jianyong" sort="Zhu, Jianyong" uniqKey="Zhu J" first="Jianyong" last="Zhu">Jianyong Zhu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan</wicri:regionArea><wicri:noRegion>Shiyan</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Qiwei" sort="Zhang, Qiwei" uniqKey="Zhang Q" first="Qiwei" last="Zhang">Qiwei Zhang</name><affiliation wicri:level="3"><nlm:affiliation>Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wu, Jianguo" sort="Wu, Jianguo" uniqKey="Wu J" first="Jianguo" last="Wu">Jianguo Wu</name><affiliation wicri:level="4"><nlm:affiliation>State Key Laboratory of Virology and College of Life Sciences, Wuhan University, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology and College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Liu, Long" sort="Liu, Long" uniqKey="Liu L" first="Long" last="Liu">Long Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan</wicri:regionArea><wicri:noRegion>Shiyan</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32100877</idno><idno type="pmid">32100877</idno><idno type="doi">10.1002/jmv.25726</idno><idno type="wicri:Area/PubMed/Corpus">000460</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000460</idno><idno type="wicri:Area/PubMed/Curation">000460</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000460</idno><idno type="wicri:Area/PubMed/Checkpoint">000440</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000440</idno><idno type="wicri:Area/Ncbi/Merge">000949</idno><idno type="wicri:Area/Ncbi/Curation">000949</idno><idno type="wicri:Area/Ncbi/Checkpoint">000949</idno><idno type="wicri:Area/Main/Merge">000473</idno><idno type="wicri:Area/Main/Curation">000471</idno><idno type="wicri:Area/Main/Exploration">000471</idno><idno type="wicri:Area/an2020/Extraction">000471</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2.</title><author><name sortKey="Liu, Zhixin" sort="Liu, Zhixin" uniqKey="Liu Z" first="Zhixin" last="Liu">Zhixin Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan</wicri:regionArea><wicri:noRegion>Shiyan</wicri:noRegion></affiliation></author><author><name sortKey="Xiao, Xiao" sort="Xiao, Xiao" uniqKey="Xiao X" first="Xiao" last="Xiao">Xiao Xiao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan</wicri:regionArea><wicri:noRegion>Shiyan</wicri:noRegion></affiliation></author><author><name sortKey="Wei, Xiuli" sort="Wei, Xiuli" uniqKey="Wei X" first="Xiuli" last="Wei">Xiuli Wei</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan</wicri:regionArea><wicri:noRegion>Shiyan</wicri:noRegion></affiliation></author><author><name sortKey="Li, Jian" sort="Li, Jian" uniqKey="Li J" first="Jian" last="Li">Jian Li</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan</wicri:regionArea><wicri:noRegion>Shiyan</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Jing" sort="Yang, Jing" uniqKey="Yang J" first="Jing" last="Yang">Jing Yang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan</wicri:regionArea><wicri:noRegion>Shiyan</wicri:noRegion></affiliation></author><author><name sortKey="Tan, Huabing" sort="Tan, Huabing" uniqKey="Tan H" first="Huabing" last="Tan">Huabing Tan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan</wicri:regionArea><wicri:noRegion>Shiyan</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Jianyong" sort="Zhu, Jianyong" uniqKey="Zhu J" first="Jianyong" last="Zhu">Jianyong Zhu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan</wicri:regionArea><wicri:noRegion>Shiyan</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Qiwei" sort="Zhang, Qiwei" uniqKey="Zhang Q" first="Qiwei" last="Zhang">Qiwei Zhang</name><affiliation wicri:level="3"><nlm:affiliation>Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wu, Jianguo" sort="Wu, Jianguo" uniqKey="Wu J" first="Jianguo" last="Wu">Jianguo Wu</name><affiliation wicri:level="4"><nlm:affiliation>State Key Laboratory of Virology and College of Life Sciences, Wuhan University, Wuhan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology and College of Life Sciences, Wuhan University, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><orgName type="university">Université de Wuhan</orgName></affiliation></author><author><name sortKey="Liu, Long" sort="Liu, Long" uniqKey="Liu L" first="Long" last="Liu">Long Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan</wicri:regionArea><wicri:noRegion>Shiyan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of medical virology</title><idno type="eISSN">1096-9071</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">From the beginning of 2002 and 2012, severe respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) crossed the species barriers to infect humans, causing thousands of infections and hundreds of deaths, respectively. Currently, a novel coronavirus (SARS-CoV-2), which has become the cause of the outbreak of Coronavirus Disease 2019 (COVID-19), was discovered. Until 18 February 2020, there were 72 533 confirmed COVID-19 cases (including 10 644 severe cases) and 1872 deaths in China. SARS-CoV-2 is spreading among the public and causing substantial burden due to its human-to-human transmission. However, the intermediate host of SARS-CoV-2 is still unclear. Finding the possible intermediate host of SARS-CoV-2 is imperative to prevent further spread of the epidemic. In this study, we used systematic comparison and analysis to predict the interaction between the receptor-binding domain (RBD) of coronavirus spike protein and the host receptor, angiotensin-converting enzyme 2 (ACE2). The interaction between the key amino acids of S protein RBD and ACE2 indicated that, other than pangolins and snakes, as previously suggested, turtles (Chrysemys picta bellii, Chelonia mydas, and Pelodiscus sinensis) may act as the potential intermediate hosts transmitting SARS-CoV-2 to humans.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li><li>Hubei</li></region><settlement><li>Jiangmen</li><li>Wuhan</li></settlement><orgName><li>Université de Wuhan</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Zhixin" sort="Liu, Zhixin" uniqKey="Liu Z" first="Zhixin" last="Liu">Zhixin Liu</name></noRegion><name sortKey="Li, Jian" sort="Li, Jian" uniqKey="Li J" first="Jian" last="Li">Jian Li</name><name sortKey="Liu, Long" sort="Liu, Long" uniqKey="Liu L" first="Long" last="Liu">Long Liu</name><name sortKey="Tan, Huabing" sort="Tan, Huabing" uniqKey="Tan H" first="Huabing" last="Tan">Huabing Tan</name><name sortKey="Wei, Xiuli" sort="Wei, Xiuli" uniqKey="Wei X" first="Xiuli" last="Wei">Xiuli Wei</name><name sortKey="Wu, Jianguo" sort="Wu, Jianguo" uniqKey="Wu J" first="Jianguo" last="Wu">Jianguo Wu</name><name sortKey="Xiao, Xiao" sort="Xiao, Xiao" uniqKey="Xiao X" first="Xiao" last="Xiao">Xiao Xiao</name><name sortKey="Yang, Jing" sort="Yang, Jing" uniqKey="Yang J" first="Jing" last="Yang">Jing Yang</name><name sortKey="Zhang, Qiwei" sort="Zhang, Qiwei" uniqKey="Zhang Q" first="Qiwei" last="Zhang">Qiwei Zhang</name><name sortKey="Zhu, Jianyong" sort="Zhu, Jianyong" uniqKey="Zhu J" first="Jianyong" last="Zhu">Jianyong Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/an2020/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000471 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/an2020/Analysis/biblio.hfd -nk 000471 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV1
|flux= an2020
|étape= Analysis
|type= RBID
|clé= pubmed:32100877
|texte= Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/an2020/Analysis/RBID.i -Sk "pubmed:32100877" \
| HfdSelect -Kh $EXPLOR_AREA/Data/an2020/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a CovidV1
| This area was generated with Dilib version V0.6.33. |  |